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Romosozumab, sold under the brand name Evenity (/ ɪ ˈ v ɛ n ɪ t i / ih-VENN-ih-tee or with the pin-pen merger, / ɪ ˈ v ɪ n ɪ t i / ih-VINN-ih-tee), is a medication used to treat osteoporosis. [ 7 ] [ 8 ] It has been found to decrease the risk of fractures of the spine .
Romosozumab (sold under the brand name Evenity) is a monoclonal antibody against sclerostin. Romosozumab is usually reserved for patients with very high fracture risk and is the only available drug therapy for osteoporosis that leads to simultaneous inhibition of bone resorption together with an anabolic effect.
Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. [3] [4] As one of the world's largest independent biotechnology companies, Amgen has approximately 24,000 staff in total as of 2022.
16973 Ensembl ENSG00000162337 ENSMUSG00000024913 UniProt O75197 Q91VN0 RefSeq (mRNA) NM_001291902 NM_002335 NM_008513 RefSeq (protein) NP_001278831 NP_002326 NP_032539 Location (UCSC) Chr 11: 68.31 – 68.45 Mb Chr 19: 3.63 – 3.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 ...
CHO cells adhered to a surface, seen under phase-contrast microscopy. Chinese hamster ovary (CHO) cells are a family of immortalized cell lines [1] derived from epithelial cells of the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of recombinant therapeutic proteins.
A first-in-class medication is a prototype drug that uses a "new and unique mechanism of action" to treat a particular medical condition. [1] While the Food and Drug Administration's Center for Drug Evaluation and Research tracks first-in-class medications and reports on them annually, first-in-class is not considered a regulatory category.
Further success came in the form of another hit, "Southern Comfort", and one gold and two silver selling albums. In the late 1970s, Flint presented the ITV show, Pop Gospel . In 1985, Flint was one of the co-presenters on the ITV television programme, Mooncat & Co .
Leukocytosis is a condition in which the white cell count is above the normal range in the blood. [1] [2] It is frequently a sign of an inflammatory response, [3] most commonly the result of infection, but may also occur following certain parasitic infections or bone tumors as well as leukemia.
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