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Salmeterol use during pregnancy must be decided based on the risks versus benefits to the mother. There are no well-controlled studies with salmeterol in pregnant women. Some animal studies showed developmental malformation when the mother was given several clinical doses orally. In rats, salmeterol xinafoate is excreted in the milk.
Salmeterol works by stimulating intracellular adenyl cyclase, which acts as a catalyst in the production of cyclic AMP. Increased cyclic AMP levels lead to a relaxation of bronchial smooth muscles. Additionally, cyclic AMP inhibits the release of mediators of immediate hypersensitivity. [2]
ATC code R03 Drugs for obstructive airway diseases is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Salmeterol: Has a N-phenylbutoxyhexyl substituent, β-hydroxyl group and a salicyl phenyl ring that gives potency and direct selectivity for β2-receptor. [14] The optimal position of the ether oxygen in the chain of Salmeterol for both potency and duration is six carbon atoms from the basic nitrogen. [18] Formoterol
A 2018 meta-analysis was unable to determine whether an increase serious adverse events reported in the previous meta-analysis on regular salmeterol alone is abolished by the additional use of regular inhaled corticosteroid. [4] Large surveillance studies are ongoing to provide more information.
Fluticasone propionate, sold under the brand names Flovent and Flonase among others, is a glucocorticoid steroid medication. [8] When inhaled it is used for the long term management of asthma and COPD. [8]
A bronchodilator or broncholytic [1] (although the latter occasionally includes secretory inhibition as well) is a substance that dilates the bronchi and bronchioles, decreasing resistance in the respiratory airway and increasing airflow to the lungs.
Fluticasone furoate is indicated for the treatment of the symptoms of allergic rhinitis, [8] and asthma. [6] [7]Fluticasone Furoate is a corticosteroid medication primarily used to treat allergic rhinitis (hay fever) and non-allergic (perennial) rhinitis.
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