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  2. Cocaine intoxication - Wikipedia

    en.wikipedia.org/wiki/Cocaine_intoxication

    Cocaine increases alertness, feelings of well-being, euphoria, energy, sociability, and sexuality. The former are some of the desired effects of cocaine intoxication. Not having the normal use of mental faculties by reason of the introduction of cocaine is defined drug intoxication by the laws in America, Europe, and most of the rest of the World, and it is a serious crime in specific contexts ...

  3. Cocaine - Wikipedia

    en.wikipedia.org/wiki/Cocaine

    Physiological and psychotropic effects from nasally insufflated cocaine are sustained for approximately 40–60 minutes after the peak effects are attained. [104] Cocaine crosses the blood–brain barrier via both a proton-coupled organic cation antiporter [18] [19] and (to a lesser extent) via passive diffusion across cell membranes. [20]

  4. Scientists Uncovered a Blow From the Past: 17th Century ... - AOL

    www.aol.com/scientists-uncovered-blow-past-17th...

    Although cocaine use became widespread in the 19th century once it was synthesized into cocaine hydrochloride salts, Europeans knew of the coca plant’s stimulating effects since the early 15th ...

  5. Epigenetics of cocaine addiction - Wikipedia

    en.wikipedia.org/wiki/Epigenetics_of_cocaine...

    Through lines of D1 receptor mutant mice, it had also been implicated in mediating both the locomotor sensation and rewarding effects of cocaine. Acute cocaine injections induced c-fos and CREB expression via D1 receptors and repeat cocaine administration, which is associated with long lasting AP-1 transcription complexes containing ΔFosB ...

  6. Psychoactive drug - Wikipedia

    en.wikipedia.org/wiki/Psychoactive_drug

    addictive drug – psychoactive substances that with repeated use are associated with significantly higher rates of substance use disorders, due in large part to the drug's effect on brain reward systems; dependence – an adaptive state associated with a withdrawal syndrome upon cessation of repeated exposure to a stimulus (e.g., drug intake)

  7. Psychopharmacology - Wikipedia

    en.wikipedia.org/wiki/Psychopharmacology

    The effects of cocaine are similar to those of amphetamines, though cocaine tends to have a shorter duration of effect. In high doses or with prolonged use, cocaine can result in a number of negative effects, including irritability, anxiety, exhaustion, total insomnia, and even psychotic symptomatology.

  8. Cocaine dependence - Wikipedia

    en.wikipedia.org/wiki/Cocaine_dependence

    Cocaine is a powerful stimulant known to make users feel energetic, cheerful, talkative, etc. In time, negative side effects include increased body temperature, irregular or rapid heart rate, high blood pressure, increased risk of heart attacks, strokes and even sudden death from cardiac arrest.

  9. Addiction - Wikipedia

    en.wikipedia.org/wiki/Addiction

    This also prevents the cocaine from crossing the blood–brain barrier, negating the euphoric high and rewarding effect of cocaine caused from stimulation of dopamine release in the mesolimbic reward pathway. The vaccine does not affect the user's "desire" for cocaine—only the physical effects of the drug. [184]