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Praziquantel is not licensed for use in humans in the UK, but it can be imported when necessary on a named-patient basis. [35] It is available in the UK as a veterinary anthelmintic. Praziquantel is FDA approved in the US for the treatment of schistosomiasis and liver flukes, although it is effective in other infections. [36]
Schistosomiasis life cycle. Source: CDC [citation needed] A Schistosomiasis vaccine is a vaccine against Schistosomiasis (also known as bilharzia, bilharziosis or snail fever), a parasitic disease caused by several species of fluke of the genus Schistosoma. No effective vaccine for the disease exists yet.
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Schistosoma mansoni is a water-borne parasite of humans, and belongs to the group of blood flukes (Schistosoma). The adult lives in the blood vessels (mesenteric veins) near the human intestine. It causes intestinal schistosomiasis (similar to S. japonicum, S. mekongi, S. guineensis, and S. intercalatum). Clinical symptoms are caused by the eggs.
Praziquantel – effective against flatworms (e.g., tapeworms and schistosoma) Octadepsipeptides (e.g. Emodepside) – effective against a variety of gastrointestinal helminths; Monepantel (aminoacetonitrile class) – effective against a variety of nematodes including those resistant to other anthelmintic classes
Arpraziquantel ((R)-praziquantel) is the eutomer (the biologically active enantiomer) of praziquantel, and is a medication which is currently under investigation for the treatment of schistosomiasis in young children since it has less side effects than the usual racemic mixture formulation of praziquantel.
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Praziquantel is the drug of choice for schistosomiasis, taeniasis, and most types of food-borne trematodiases. Oxamniquine is also widely used in mass deworming programmes. Pyrantel is commonly used for veterinary nematodiasis. [45] [46] Artemisinins and derivatives are proving to be candidates as drugs of choice for trematodiasis. [47]
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