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A BiTE linking a T cell to a tumor cell. Like other bispecific antibodies, and unlike ordinary monoclonal antibodies, BiTEs form a link between T cells and tumor cells. This causes T cells to exert cytotoxic activity on tumor cells by producing proteins like perforin and granzymes, independently of the presence of MHC I or co-stimulatory molecules.
Epcoritamab, sold under the brand name Epkinly, is a monoclonal antibody anticancer medication used for the treatment of diffuse large B-cell lymphoma. [4] [7] Epcoritamab is a bispecific CD20-directed CD3 T-cell engager. [4] [7] Epcoritamab was co-developed by AbbVie and Genmab. [8]
Glofitamab, sold under the brand name Columvi, is a bispecific monoclonal antibody used for the treatment of large B-cell lymphoma. [10] It is a bispecific CD20-directed CD3 T-cell engager developed by Roche. [7] The most common side effects include cytokine release syndrome, muscle and bone pain, rash, and tiredness. [11]
TNB-486 (also known as AZD0486) [1] "is a novel CD19x CD3 bispecific T-cell engager (TCE) that incorporates a unique anti-CD3 moiety designed to reduce cytokine release syndrome by binding to T-cells with low affinity". [2] The drug is developed for cancer by AstraZeneca since its acquisition of TeneoTwo in 2022. [3] [4] [5]
[1] [9] It is a bispecific GPRC5D-directed CD3 T-cell engager. [1] Talquetamab is a bispecific antibody against two targets: human CD3, a T-cell surface antigen, and human G-protein coupled receptor family C group 5 member D (GPRC5D), a tumor-associated antigen with potential antineoplastic activity. [11]
The FDA has approved Immunocore Holdings plc (NASDAQ: IMCR) (tebentafusp-tebn) for HLA-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma (mUM). Marketed as Kimmtrak ...
T cell deficiency is a deficiency of T cells, caused by decreased function of individual T cells, it causes an immunodeficiency of cell-mediated immunity. [1] T cells normal function is to help with the human body's immunity, they are one of the two primary types of lymphocytes (the other being B cells ).
Woman was last seen on Dec. 17. "Known acquaintance" has been charged with murder after body parts were found in his car.