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Lisch nodule, also known as iris hamartoma, is a pigmented hamartomatous nodular aggregate of dendritic melanocytes affecting the iris, [1] named after Austrian ophthalmologist Karl Lisch (1907–1999), who first recognized them in 1937.
Lisch nodule: Karl Lisch: ophthalmology: type I neurofibromatosis: yellow brown hamartomata on iris Lisker's sign? internal medicine: deep venous thrombosis (needed) tenderness on percussion of antero-medial tibia Litten's sign: Moritz Litten: cardiology: infective endocarditis: eMedicine: cotton-wool exudate in the retina Lombard effect ...
Lisch nodules – iris hamartomas seen in neurofibromatosis. Ocular melanosis – a condition characterized by increased pigmentation of the uveal tract , episclera , and anterior chamber angle. Oculodermal melanocytosis (nevus of Ota) [ 3 ]
Brushfield spots are small, white or greyish/brown spots on the periphery of the iris in the human eye due to aggregation of connective tissue, a normal constituent of the iris stroma. The spots are named after the physician Thomas Brushfield, who first described them in his 1924 M.D. thesis. [1]
Watson syndrome is an autosomal dominant condition characterized by Lisch nodules of the ocular iris, axillary/inguinal freckling, pulmonary valvular stenosis, relative macrocephaly, short stature, and neurofibromas. [1] Watson syndrome is allelic to NF1, the same gene associated with neurofibromatosis type 1. [2]
Features common in neurofibromatosis – like Lisch nodules (iris hamartomas diagnosed on slit lamp exam), bone abnormalities, neurofibromas, optic pathway gliomas and malignant peripheral nerve sheath tumors – are absent in Legius syndrome. [1]
Lisch nodules (benign hamartomas of the iris) are seen in almost all patients but they do not cause any visual or ocular impairment. Neurofibromas are benign nerve sheath tumors that occur in peripheral nerves. These typically develop during the teenage years.
At least two growths on the eye's iris; Abnormal growth of the spine ; Lisch nodules; Tumors on the adrenal glands called pheochromocytomas; People with neurofibromatosis type 2 can exhibit the same type of skin symptoms as type 1, but not necessarily in every case. [10]