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For example, when individuals suffer from a mutation that causes them to have low levels of serotonin, there is an observed increase in impulsivity and depression [8] With neurotransmitters playing a central role in the development of aggressive behaviour, it follows that many of the gene mutations that have been implicated with aggressive ...
Huntington's disease (HD) is a rare autosomal dominant neurodegenerative disorder caused by mutations in the huntingtin gene (HTT). HD is characterized by loss of medium spiny neurons and astrogliosis. [30] [31] [32] The first brain region to be substantially affected is the striatum, followed by degeneration of the frontal and temporal ...
The hallmark symptom of LATE is a progressive memory loss that predominantly affects short-term and episodic memory. [1] This impairment is often severe enough to interfere with daily functioning and usually remains the chief neurologic deficit, unlike other types of dementia in which non-memory cognitive domains and behavioral changes might be noted earlier or more prominently. [1]
[50] [51] [52] Mice defective in a gene (Pms2) that ordinarily corrects base mispairs in DNA have about a 100-fold elevated mutation frequency in all tissues, but do not appear to age more rapidly. [53] On the other hand, mice defective in one particular DNA repair pathway show clear premature aging, but do not have elevated mutation. [54]
Hering and Semon developed general theories of memory, the latter inventing the idea of the engram and concomitant processes of engraphy and ecphory. Semon divided memory into genetic memory and central nervous memory. [7] This 19th-century view is not wholly dead, albeit that it stands in stark contrast to the ideas of neo-Darwinism. In modern ...
By the final stages of Alzheimer's, this process – called brain atrophy – is widespread, causing significant loss of brain volume. This loss of brain volume affects ones ability to live and function properly, ultimately being fatal. [33] Beta-amyloid is a small piece of a larger protein called amyloid precursor protein (APP). Once APP is ...
According to the World Health Organization, nearly 1 in 6 people worldwide are living with a neurological disorder. In the U.S. alone, approximately 5.8 million people have Alzheimer's disease ...
Brain areas that undergo significant post-natal development, such as those involved in memory and emotion are more vulnerable to effects of early life stress. [ 58 ] [ 64 ] For example, the hippocampus continues to develop after birth and is a structure that is affected by childhood maltreatment. [ 64 ]