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Pentachlorophenol (PCP) is an organochlorine compound used as a pesticide and a disinfectant. First produced in the 1930s, it is marketed under many trade names. [5] It can be found as pure PCP, or as the sodium salt of PCP, the latter of which dissolves easily in water. It can be biodegraded by some bacteria, including Sphingobium ...
Chemically, PCP is a member of the arylcyclohexylamine class, and pharmacologically, it is a dissociative anesthetic. [4][9][10] PCP works primarily as an NMDA receptor antagonist. [9] PCP is most commonly used in the US. [11] While usage peaked in the US in the 1970s, [12] between 2005 and 2011 an increase in visits to emergency departments as ...
Doses as high as 15–20 mg/kg are taken by some recreational users. A single case study suggests that the antidote to dextromethorphan overdose is naloxone, administered intravenously. [17] In addition to producing PCP-like mental effects, high doses may cause a false-positive result for PCP and opiates in some drug tests. [9] [18]
Dextromethorphan (DXM), sold under the trade name Robitussin among others, is a cough suppressant used in many cough and cold medicines. [6] In 2022, the FDA approved the combination dextromethorphan/bupropion to serve as a rapid acting antidepressant in patients with major depressive disorder.
Pneumococcal conjugate vaccine is a pneumococcal vaccine made with the conjugate vaccine method and used to protect infants, young children, and adults against disease caused by the bacterium Streptococcus pneumoniae (pneumococcus). It contains purified capsular polysaccharide of pneumococcal serotypes conjugated to a carrier protein to improve ...
An arylcyclohexylamine is composed of a cyclohexylamine unit with an aryl moiety attachment. The aryl group is positioned geminal to the amine. In the simplest cases, the aryl moiety is typically a phenyl ring, sometimes with additional substitution. The amine is usually not primary; secondary amines such as methylamine or ethylamine, or ...
Foods like tofu, prunes, kale, yogurt, salmon and tahini are some of the best foods you should be eating more of for better bone health. In addition, be sure to stay physically active, keep close ...
The high affinity of 3-HO-PCP for opioid receptors is unique among arylcyclohexylamines and is in contrast to PCP, which has only very low affinity for the MOR (K i = 11,000–26,000 nM; 282- to 433-fold difference) and the other opioid receptors (K i = 4,100 nM for the KOR and 73,000 nM for the DOR).