Search results
Results from the WOW.Com Content Network
Testosterone is the primary male sex hormone and androgen in males. [3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testicles and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.
The elimination half-life of DHT in the body (53 minutes) is longer than that of testosterone (34 minutes), and this may account for some of the difference in their potency. [51] A study of transdermal (patches) DHT and testosterone treatment reported terminal half-lives of 2.83 hours and 1.29 hours, respectively.
The HPG axis plays a critical part in the development and regulation of a number of the body's systems, such as the reproductive and immune systems. Fluctuations in this axis cause changes in the hormones produced by each gland and have various local and systemic effects on the body. The axis controls development, reproduction, and aging in ...
Conversely, “with too much testosterone, women often have acne, too much hair on the body, hair loss on the head, high blood pressure, elevated cholesterol, skipped cycles, or problems ...
Only certain organs in the body, such as the gonads and the adrenal glands, produce the androgen testosterone. Testosterone is converted into dihydrotestosterone, a chemically similar androgen, in cells containing the enzyme 5-alpha reductase. Both androgens exert their influence through binding with the androgen receptor.
Dihydrotestosterone (DHT) is a metabolite of testosterone, and a more potent androgen than testosterone in that it binds more strongly to androgen receptors. It is produced in the skin and reproductive tissue. A4 and testosterone can also have an extra hydroxyl (-OH) or keton (=O) group bound on position 11.
Testosterone levels very with age, according to the Cleveland Clinic, and start to drop around age 30 or 40. Women turn to weight loss drugs in menopause: What to know about the benefits and risks
[29] [30] Combined marked suppression of testicular testosterone production resulting in testosterone levels of just above the castrate/female range (70 to 80% decrease, to 100 ng/dL on average) and marked androgen receptor antagonism with high-dosage cyproterone acetate monotherapy causes profound sexual dysfunction in men.