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  2. David A. Sinclair - Wikipedia

    en.wikipedia.org/wiki/David_A._Sinclair

    David Andrew Sinclair AO (born June 26, 1969) is an Australian-American biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and the founding director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard.

  3. Sirtris Pharmaceuticals - Wikipedia

    en.wikipedia.org/wiki/Sirtris_Pharmaceuticals

    Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. Conceived in 2004 by Harvard University biologist David Sinclair and Andrew Perlman, [1] and founded that year by Sinclair and Perlman, along with Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, [2] the company was ...

  4. Sirtuin-activating compound - Wikipedia

    en.wikipedia.org/wiki/Sirtuin-activating_compound

    STACs have been discovered by Konrad Howitz of Biomol Inc and biologist David Sinclair. In September 2003, Howitz and Sinclair et al. published a highly cited paper reporting that polyphenols such as resveratrol [ 2 ] activate human SIRT1 and extend the lifespan of budding yeast (Howitz et al., Nature, 2003).

  5. Resveratrol - Wikipedia

    en.wikipedia.org/wiki/Resveratrol

    [53] [57] [58] [59] In 2004, Harvard University professor David Sinclair co-founded Sirtris Pharmaceuticals, the initial product of which was a resveratrol formulation. [60] [61] [62] Sirtris was purchased and made a subsidiary of GlaxoSmithKline in 2008 for $720 million and shut down in 2013, without successful drug development. [63] [64]

  6. Christoph Westphal - Wikipedia

    en.wikipedia.org/wiki/Christoph_Westphal

    In 2004, he co-founded Sirtris Pharmaceuticals as CEO with Harvard biologist David Sinclair, serial entrepreneur Andrew Perlman, Richard Aldrich, Richard Pops, and Paul Schimmel. [19] [20] The company focused on resveratrol formulations and derivatives as activators of the SIRT1 enzyme.

  7. Diontae Johnson traded to Baltimore Ravens: Fantasy football ...

    www.aol.com/sports/diontae-johnson-traded...

    Elsewhere on the roster, veteran receiver David Moore, who has familiarity with Dave Canales from Seattle and Tampa Bay, stepped into Johnson’s vacated X-receiver role last week and led the team ...

  8. I Let ChatGPT Train Me for a Month—and the Results ... - AOL

    www.aol.com/let-chatgpt-train-month-results...

    Sound advice. I did what it suggested, and still had pretty solid workouts. You might have also noticed that the bot didn’t specify what equipment to use, or what style to do for a handful of ...

  9. Leonard P. Guarente - Wikipedia

    en.wikipedia.org/wiki/Leonard_P._Guarente

    In 1991 his lab started to study genes involved in aging. [5] In 1993, Cynthia Kenyon 's lab at UCSF discovered that a single-gene mutation in ( Daf-2 ) could double the lifespan of C. elegans . That same year, David Sinclair joined the Guarente lab, and they developed the hypothesis that caloric restriction slows aging by activation of ...