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Pepsin exhibits a broad cleavage specificity. Pepsin will digest up to 20% of ingested amide bonds. [18] Residues in the P1 and P1' positions [19] are most important in determining cleavage probability. Generally, hydrophobic amino acids at P1 and P1' positions increase cleavage probability.
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe 1 -Val, Gln 4 -His, Glu 13 -Ala, Ala 14 -Leu, Leu 15 -Tyr, Tyr 16 -Leu, Gly 23 -Phe, Phe 24 -Phe and Phe 25 -Tyr bonds in the B chain of insulin
Aspergillopepsin I (EC 3.4.23.18, Aspergillus acid protease, Aspergillus acid proteinase, Aspergillus aspartic proteinase, Aspergillus awamori acid proteinase, Aspergillus carboxyl proteinase, carboxyl proteinase, Aspergillus kawachii aspartic proteinase, Aspergillus saitoi acid proteinase, pepsin-type aspartic proteinase, Aspergillus niger acid proteinase, sumizyme AP, proctase P, denapsin ...
In obstetrics, position is the orientation of the fetus in the womb, identified by the location of the presenting part of the fetus relative to the pelvis of the mother. Conventionally, it is the position assumed by the fetus before the process of birth, as the fetus assumes various positions and postures during the course of childbirth .
Progesterone causes many changes to the genitourinary system. A pregnant woman may experience an increase in the size of the kidneys and ureter due to the increase blood volume and vasculature. Later in pregnancy, the woman might develop physiological hydronephrosis and hydroureter, which are normal. [33]
Although described as "morning sickness," pregnant women can experience this nausea any time of day or night. The exact cause of morning sickness remains unknown. Nausea and vomiting in pregnancy is typically mild and self-limited, resolving on its own by the 14th week of pregnancy. Other causes should also be ruled out when considering treatment.
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Definition: Relationship between the longitudinal axis of fetus and mother: longitudinal (resulting in either cephalic or breech presentation) oblique (unstable, will eventually become either transverse or longitudinal) transverse (resulting in shoulder presentation) back up; back down (indication for vertical uterine incision during cesarean ...