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The kidney's ability to perform many of its functions depends on the three fundamental functions of filtration, reabsorption, and secretion, whose sum is called renal clearance or renal excretion. That is: Urinary excretion rate = Filtration rate – Reabsorption rate + Secretion rate [1]
Filtration, which takes place at the renal corpuscle, is the process by which cells and large proteins are retained while materials of smaller molecular weights are [30] filtered from the blood to make an ultrafiltrate that eventually becomes urine.
C. Podocytes: 1. enzymatic and structural protein 2. filtration slit 3. diaphragma Podocytes have primary processes called trabeculae, which wrap around the glomerular capillaries . [ 2 ] The trabeculae in turn have secondary processes called pedicels or foot processes. [ 2 ]
This process is called ultrafiltration; the resulting fluid, virtually free of large proteins and blood cells, is referred to as glomerular filtrate, or ultrafiltrate. [1] Further modification of ultrafiltrate, by reabsorption and secretion, transforms it into urine. Glomerular pressure is about 75 millimeters of mercury (10 kPa). It is opposed ...
The four mechanisms used to create and process the filtrate (the result of which is to convert blood to urine) are filtration, reabsorption, secretion and excretion. Filtration or ultrafiltration occurs in the glomerulus and is largely passive: it is dependent on the intracapillary blood pressure. About one-fifth of the plasma is filtered as ...
The glomerulus and its surrounding Bowman's capsule constitute a renal corpuscle, the basic filtration unit of the kidney. [2] The rate at which blood is filtered through all of the glomeruli, and thus the measure of the overall kidney function, is the glomerular filtration rate.
The kidney has many functions, which a well-functioning kidney realizes by filtering blood in a process known as glomerular filtration. A major measure of kidney function is the glomerular filtration rate (GFR). The glomerular filtration rate is the flow rate of filtered fluid through the kidney.
These pedicels interdigitate with pedicels of adjacent podocytes forming filtration slits. There are two poles in the renal corpuscle, a vascular pole and a tubular pole. [4] The vascular pole is a location of the glomerulus. At the vascular pole, the afferent arterioles and efferent arterioles enter and leave the glomerulus in the Bowman's ...