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Spironolactone; Clinical data; Pronunciation / ˌ s p aɪ r oʊ n oʊ ˈ l æ k t oʊ n / SPY-roh-noh-LAK-tone, [1] / ˌ s p ɪər oʊ n oʊ ˈ l æ k t oʊ n / SPEER-oh-noh-LAK-tone [2] Trade names: Aldactone, others
Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. [5] [6] [7] The active metabolites of spironolactone have extended terminal half-lives of 13.8 hours for 7α-TMS, 15.0 hours for 6β-OH-7α-TMS, and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug. [5] [6]
However, spironolactone is metabolized to three active metabolites, which give it prolonged activity (13.8 – 16. 5 hours). Spironolactone has a long half-life and is excreted 47-51% through kidneys. Patients with chronic kidney disease therefore require close monitoring when taking the drug. Spironolactone is also eliminated through feces (35-41%
Seattle Genetics (NAS: SGEN) fell quite a bit after the company announced a change to the warnings section of the label for its blood cancer drug Adcetris. The label warns of a possible link to a ...
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Teva Pharmaceutical Industries Ltd. (also known as Teva Pharmaceuticals) is an Israeli multinational pharmaceutical company. Teva specializes primarily in generic drugs , but other business interests include branded-drugs, active pharmaceutical ingredients (APIs) and, to a lesser extent, contract manufacturing services and an out-licensing ...
Teva has several biosimilars - copies of high-priced drugs - and net debt is down to $16.6 billion. High debt from a failed acquisition in 2017 has held Teva back from further M&A deals, Francis said.
Dutasteride is sometimes used as a component of hormone therapy for transgender women in combination with an estrogen and/or another antiandrogen such as spironolactone. [7] It may be useful for preventing and treating scalp hair loss and can also be used as a general antiandrogen for in those who have issues tolerating spironolactone, though as a α-reductase inhibitor it has limited effects ...