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Individuals with Addison's disease have more than a doubled mortality rate. [37] Furthermore, individuals with Addison's disease and diabetes mellitus have an almost four-fold increase in mortality compared to individuals with only diabetes. [38] The risk ratio for cause mortality in males and females is 2.19 and 2.86, respectively. [37]
Acanthosis nigricans is a medical sign characterised by brown-to-black, poorly defined, velvety hyperpigmentation of the skin. [1] It is usually found in body folds, [2] such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead and other areas.
Hyperpigmentation can be caused by sun damage, inflammation, or other skin injuries, including those related to acne vulgaris. [1] [2] [3]: 854 People with darker skin tones are more prone to hyperpigmentation, especially with excess sun exposure. [4] Many forms of hyperpigmentation are caused by an excess production of melanin. [4]
"Hyperpigmentation just means darkening of the skin," says Dr. Dowling. "So basically, 'hyperpigmentation' is an umbrella term for lots of different conditions that cause hyperpigmentation ...
The disease can cause dangerously low cortisol levels, ... It can also cause hyperpigmentation, or a darkening of the skin that can make people appear bronzed. ... Addison's disease is treatable ...
The disease referred to a chronic progressive adrenal insufficiency, and was described in 1855 by the Englishman Thomas Addison, who gave it his name, Addison's disease. [9] The cardinal signs included asthenia , low blood pressure , anorexia (with weight loss) and melanoderma, with hyperpigmentation of the skin at friction points and of the ...
Addison's disease can be caused by a variety of pathological processes. It is an endocrinal disorder where there is an increased amount of adrenocorticotropic hormone (ACTH) as a result of deficient amounts of hormones being produced from the adrenal cortex. [9] Due to this, dark pigmentation may be visible on the oral mucosa or skin. [10]
Nelson's syndrome is a disorder that occurs in about one in four patients who have had both adrenal glands removed to treat Cushing's disease. [1] In patients with pre-existing adrenocorticotropic hormone ()-secreting pituitary adenomas, loss of adrenal feedback following bilateral adrenalectomy can trigger the rapid growth of the tumor, leading to visual symptoms (e.g. bitemporal hemianopsia ...