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Whole genome sequencing (WGS) is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time. [2] This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast .
Illumina also uses the DNA colony sequencing technology, invented in 1997 by Pascal Mayer and Laurent Farinelli [7] and which was acquired by Solexa in 2004 from Manteia Predictive Medicine. It is being used to perform a range of analyses, including whole genome resequencing, gene-expression analysis, and small ribonucleic acid (sRNA) analysis.
The ruling also stated Illumina infringed the patents wilfully, and that three patents it had accused BGI's Complete Genomics subsidiary of infringing were invalid. [95] In July 2022 Illumina and MGI Tech Co. and Complete Genomics, settled US suits on DNA-sequencing technology, with Illumina agreeing to pay $325 million to settle all US litigation.
In a separate partnership with Broad Institute and Harvard, San Diego-based Illumina will work on research sequencing of single cells and conduct experiments using technology from the company's ...
In terms of genomic coverage and accuracy, whole genome sequencing can broadly be classified into either of the following: [13] A draft sequence, covering approximately 90% of the genome at approximately 99.9% accuracy; A finished sequence, covering more than 95% of the genome at approximately 99.99% accuracy
The whole genome sequencing technique was first applied to the DNA methylation mapping at single nucleotide resolution to Arabidopsis thaliana in 2008, and shortly after in 2009, the first single-base-resolution DNA methylation map of the entire human genome was created using whole genome bisulfite sequencing.
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