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Dexmedetomidine, sold under the brand name Precedex among others, is a medication used for sedation. [4] Veterinarians use dexmedetomidine for similar purposes in treating cats, dogs, and horses. [ 10 ] [ 11 ] It is also used in humans to treat acute agitation associated with schizophrenia or bipolar disorder . [ 5 ]
Drug titration is the process of adjusting the dose of a medication for the maximum benefit without adverse effects. [ 1 ] When a drug has a narrow therapeutic index , titration is especially important, because the range between the dose at which a drug is effective and the dose at which side effects occur is small. [ 2 ]
Medetomidine is a racemic mixture of two optical or stereoisomers, levomedetomidine and dexmedetomidine. [4] The latter causes the alpha 2- adrenergic agonist effects. [5] It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid that can be administered as an intravenous drug solution with sterile water.
Aripiprazole (Abilify) – atypical antipsychotic (non-selective monoamine receptor modulator) [1]; Bupropion/dextromethorphan (AXS-05; Auvelity) – sigma σ 1 receptor agonist, serotonin reuptake inhibitor, norepinephrine and dopamine reuptake inhibitor, nicotinic acetylcholine receptor negative allosteric modulator, ionotropic glutamate NMDA receptor antagonist, other actions, and CYP2D6 ...
The glucose clamp technique was developed by University of Texas (UT) School of Medicine Professors DeFronzo, Andres and Tobin in 1979. [2] It has since been the gold standard for pharmacodynamic studies in diabetes drug development and diagnostics evaluation. [3]
They are mainly used in research, having found limited clinical application in human medicine. They are extensively used in veterinary medicine to reverse the effects of alpha-2 agonist drugs used as sedatives, like xylazine, medetomidine and dexmedetomidine. Alpha-2 blockers increase noradrenaline release.
Richard K. Bernstein (born June 17, 1934) is a physician and an advocate for a low-carbohydrate diabetes diet to help achieve normal blood sugars for diabetics. Bernstein has type 1 diabetes . His private medical practice in Mamaroneck, New York is devoted solely to treating diabetes and prediabetes.
Splay is usually used in reference to glucose; [1] other substances, such as phosphate, have virtually no splay at all. The splay in the glucose titration curve is likely a result of both anatomical and kinetic difference among nephrons. [7] A particular nephron's filtered load of glucose may be mismatched to its capacity to reabsorb glucose.