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Today, fluid bed units are available for batch as well as for continuous production. Further technologies include wet granulation as well as film and sugar coating. These technologies are applied: in the pharmaceutical industry for production of Granules, tablets and dragées; Pellets, capsules; Ointments, creams; Suppositories; Blood plasma ...
A film coating is a thin polymer-based coat that is typically sprayed onto solid pharmaceutical dosage forms, such as tablets, capsules, pellets or granules.Film coating can impact both its appearance and its pharmacokinetics making it an essential process in making the final drug product.
ACG Engineering provides Machines for the oral Solid dosage part of the pharma industry, right from granulation equipment, capsule filling machines, tablet press, tablet coaters, tablet tooling, and packaging machines like blister packing and Cartoning machines. [10] ACG has completed more than 20,000 machine installations. [11]
There are two types of coating machines used in the pharmaceutical industry: coating pans and automatic coaters. [14] Coating pans are used mostly to sugar coat pellets. Automatic coaters are used for all kinds of coatings; they can be equipped with a remote control panel, a dehumidifier, and dust collectors.
Pharmaceutical manufacturing is the process of industrial-scale synthesis of pharmaceutical drugs as part of the pharmaceutical industry. The process of drug manufacturing can be broken down into a series of unit operations , such as milling , granulation , coating , tablet pressing , and others.
Slot-die coating is a non-contact coating method, in which the slot-die is typically held over the substrate at a height several times higher than the target wet film thickness. [23] The coating fluid transfers from the slot-die to the substrate via a fluid bridge that spans the air gap between the slot-die lips and substrate surface.
The BFS process functions similarly to conventional extrusion blow molding, and takes place within a BFS machine. [6] First, a plastic polymer resin is heated to >160 °C and compressed to 35 MPa, [11] [15] allowing it to be extruded in tubular form, [1] and be taken over by an open two-part [16] mold to form the container.
With this framework – according to Hinz [2] – the FDA tries to motivate the pharmaceutical industry to improve the production process. Because of the tight regulatory requirements and the long development time for a new drug, the production technology is "frozen" at the time of conducting phase-2 clinical trials.
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