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Brodmann area 33, also known as pregenual area 33, is a subdivision of the cytoarchitecturally defined cingulate region of cerebral cortex.It is a narrow band located in the anterior cingulate gyrus adjacent to the supracallosal gyrus in the depth of the callosal sulcus, near the genu of the corpus callosum. [1]
The anterior cingulate cortex can be divided anatomically based on cognitive , and emotional components. [5] The dorsal part of the ACC is connected with the prefrontal cortex and parietal cortex , as well as the motor system and the frontal eye fields , [ 6 ] making it a central station for processing top-down and bottom-up stimuli and ...
The cingulate cortex is usually considered part of the limbic lobe. It receives inputs from the thalamus and the neocortex, and projects to the entorhinal cortex via the cingulum. It is an integral part of the limbic system, which is involved with emotion formation and processing, [1] learning, [2] and memory.
It is located beneath the cingulate gyrus within the medial surface of the brain therefore encircling the entire brain. There are two primary parts of the cingulate cortex: the posterior cingulate cortex and the anterior cingulate cortex. The anterior is linked to emotion, especially apathy and depression. Here function and structure changes ...
Emotional lateralization is the asymmetrical representation of emotional control and processing in the brain. There is evidence for the lateralization of other brain functions as well. Emotions are complex and involve a variety of physical and cognitive responses, many of which are not well understood.
The pathophysiology of this disease revolves around a disconnect between the insular cortex secondary to damage and the limbic system, specifically the cingulate gyrus whose prime response to the pain perceived by insular cortex is to tether it with an agonizing emotional response thus signaling the individual of its propensity to inflict ...
Bilateral cingulotomy targets the anterior cingulate cortex, which is a part of the limbic system. This system is responsible for the integration of feelings and emotion in the human cortex. It consists of the cingulate gyrus, parahippocampal gyrus, amygdala, and the hippocampal formation. [8]
Notably, the anterior cingulate cortex is thought to be responsible for emotional responses to pain, including perceived social or emotional pain. Reducing nociceptive signaling to this area not only reduces overall pain signaling, but appears to also reduce sensitivity to pain.