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Colonic crypts (intestinal glands) within four tissue sections. In panel A, the bar shows 100 μm and allows an estimate of the frequency of crypts in the colonic epithelium. Panel B includes three crypts in cross-section, each with one segment deficient for CCOI expression and at least one crypt, on the right side, undergoing fission into two ...
The Crypts of Lieberkühn (intestinal glands) are named for him; he first described these in detail in De fabrica et actione vollorum intestinorum tenuium hominis, in 1745. Beyond this, Lieberkühn produced optical instruments such as compass microscopes with Lieberkühn reflector , further developing the light microscope , which he had seen ...
Crypts are anatomical structures that are narrow but deep invaginations into a larger structure. One common type of anatomical crypt is the Crypts of Lieberkühn. [1] However, it is not the only type: some types of tonsils also have crypts. Because these crypts allow external access to the deep portions of the tonsils, these tonsils are more ...
The gastrointestinal tract is composed of numerous cell types that are important for immune activation and barrier surface defenses. The gastrointestinal epithelium is composed of enterocytes, goblet cells, Paneth cells, enteroendocrine cells, tuft cells, and stem cells.
For decades, it was believed that the main function of the glands is to secrete alkaline (bicarbonate-containing) mucus in order to: [citation needed] protect the duodenum from the acidic content of chyme (which enters the duodenum from the stomach), provide an alkaline environment which promotes the activity of intestinal enzymes,
331063 Ensembl n/a ENSMUSG00000056293 UniProt Q9BYG8 Q2KHK6 RefSeq (mRNA) NM_031415 NM_001168274 NM_177912 RefSeq (protein) NP_113603 NP_001161746 NP_808580 Location (UCSC) n/a Chr 15: 63.7 – 63.72 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Gasdermin C is a protein that in humans is encoded by the GSDMC gene. References ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056293 ...
Enterochromaffin (EC) cells (also known as Kulchitsky cells) are a type of enteroendocrine cell, and neuroendocrine cell.They reside alongside the epithelium lining the lumen of the digestive tract and play a crucial role in gastrointestinal regulation, particularly intestinal motility and secretion. [1]
More recently, through loss-of-function and rescue-phenotype studies, RANKL is shown to be a receptor activator of NF-κB ligand and play a role in differentiation of M cells. RANKL is expressed throughout the small intestine, facilitates uptake of pathogens such as Salmonella, and is the most critical factor M cell differentiation. [ 5 ]