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Paraphrenia is often associated with a physical change in the brain, such as a tumor, stroke, ventricular enlargement, or neurodegenerative process. [4] Research that reviewed the relationship between organic brain lesions and the development of delusions suggested that "brain lesions which lead to subcortical dysfunction could produce delusions when elaborated by an intact cortex".
John Haslam (1764–1844) was an English apothecary, physician and medical writer, known for his work on mental illness.Haslam's case study of James Tilly Matthews is the earliest detailed description of paranoid schizophrenia.
Schizophrenia is diagnosed 1.4 times more frequently in males than females, with onset peaking at ages 20–28 years for males and 4–10 years later in females. [24] Females show more psychotic and affective symptoms than males, and have less social impairment. Men present more often with negative symptoms and disorganization. [2]
The first of these, in 1884-1885 was what was then diagnosed as dementia praecox (later known as paranoid schizophrenia or schizophrenia, paranoid type). He described his second mental illness , from 1893 to 1902, making also a brief reference to the first disorder from 1884 to 1885, in his book Memoirs of A Nervous Illness ( German ...
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Schizophrenia affects around 0.3–0.7% of people at some point in their life. [19] [14] In areas of conflict this figure can rise to between 4.0 and 6.5%. [254] It occurs 1.4 times more frequently in males than females and typically appears earlier in men. [87] Worldwide, schizophrenia is the most common psychotic disorder. [56]
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The disadvantageous-byproduct view hypothesizes that schizophrenia started to occur when humans diverged from primates. According to this view, schizophrenia symptoms are extreme versions of normal social behaviors. [6] Symptoms of schizophrenia such as delusions are extreme versions of cognitive processes that can be greatly beneficial.