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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution; although, only in a few cases are genes the primary cause of obesity. [4] [5]
"Your genes can play a role in your body shape and how easily you gain weight. While you can't change your genetics, understanding the cause can help reduce frustration," says Best. 23.
Pathological causes of weight gain include Cushing's syndrome, hypothyroidism, insulinoma, and craniopharyngioma. Genetic reasons can relate to Prader–Willi syndrome, Bardet–Biedl syndrome, Alström syndrome, Cohen syndrome, and Carpenter syndrome.
The extreme endpoint of this distribution are the so-called 'monogenic' obesities where most of the impact on body weight can be tied to a mutation in a single gene that runs in a single family. The classic example of such a genetic effect is the presence of mutations in the leptin gene. [29]
A “hungry gut” gene may indicate who responds best to weight loss drugs like Ozempic and Wegovy, new research finds. “Hungry gut” refers to the type of obesity phenotype that occurs when ...
“There are many medications that may cause weight gain,” says W. Scott Butsch, M.D., director of obesity medicine in the Bariatric and Metabolic Institute at the Cleveland Clinic.
Myostatin-related muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. [1] Affected individuals have up to twice the usual amount of muscle mass in their bodies, but increases in muscle strength are not usually congruent. [2]
Dr Browning said: “We have yet to find out whether the loss of astrocyte activity and the signalling mechanism is the cause of overeating or that it occurs in response to the overeating.