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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [8] [9] It may also be used for hiccups and muscle spasms near the end of life, [9] and off-label to treat alcohol use disorder [10] [11] or opioid withdrawal symptoms. [12]
Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
Side effects of thiocolchicoside can include nausea, allergy and vasovagal reactions. [15] Liver injury, pancreatitis, seizures, blood cell disorders, severe cutaneous disorders, rhabdomyolysis, and reproductive disorders have all been recorded in the French and European pharmacovigilance databases and in the periodic updates that the companies concerned submit to regulatory agencies.
Tizanidine, sold under the brand name Zanaflex among others, is an alpha-2 (α 2) adrenergic receptor agonist, [2] similar to clonidine, that is used to treat muscle spasticity due to spinal cord injury, multiple sclerosis, and spastic cerebral palsy. [3] Effectiveness appears similar to baclofen or diazepam. [4] It is taken by mouth. [5]
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Police had said the children, ages 6 to 10, were in "extreme danger." It's unclear whether Davison has an attorney. Contributing: USA TODAY staff. Greta Cross is a national trending reporter at ...
Dual-use items refers to those that can be used for either civilian or military purposes. China also sanctioned 10 defense firms on Thursday over military sales to Taiwan, the self-governing ...
Alcohol can be used to self-medicate against muscle spasm. Clearly not a good idea. If the user was honest about his/her use of alcohol, and baclofen were substituted for alcohol, obviously baclofen would trump the alcohol. The writer Christy Brown probably used alcohol in this way Wythy 14:48, 12 November 2016 (UTC)
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