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The members of the LDLR family are characterized by distinct functional domains present in characteristic numbers. These modules are: LDL receptor type A (LA) repeats of 40 residues each, displaying a triple-disulfide-bond-stabilized negatively charged surface; certain head-to-tail combinations of these repeats are believed to specify ligand ...
It is caused by the presence of antibodies against anionic phospholipids and β2-glycoprotein I (β2GPI). The anti-β2GPI antibodies are most prevalent in causing the symptoms of the disease. When bound by an antibody, β2GPI begins to interact with monocytes, endothelial cells, and platelets. ApoER2 is thought to play a key role in the process ...
Suppression of receptor-binding domain of LRP LDLR is due to overexpression of LRPAP (the protein product of LRPAP gene). [13] LRP gives protection across LDL by LRPAP and its downregulation may be subjected for an elevation of LDL and Ab-related neuronal toxicity as LRP supports in binding of ligand and internalization of LRP ligands like apo ...
[8] [10] [11] As a member of the LDLR family, LRP1 contains cysteine-rich complement-type repeats, EGF (gene) repeats, β-propeller domains, a transmembrane domain, and a cytoplasmic domain. [9] The extracellular domain of LRP1 is the alpha-chain, which comprises four ligand -binding domains (numbered I-IV) containing two, eight, ten, and ...
The LDLR gene resides on chromosome 19 at the band 19p13.2 and is split into 18 exons. [8] Exon 1 contains a signal sequence that localises the receptor to the endoplasmic reticulum for transport to the cell surface.
228357 Ensembl ENSG00000134569 ENSMUSG00000027253 UniProt O75096 Q8VI56 RefSeq (mRNA) NM_002334 NM_001145857 NM_172668 RefSeq (protein) NP_002325 NP_001139329 NP_766256 Location (UCSC) Chr 11: 46.86 – 46.92 Mb Chr 2: 91.29 – 91.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Low-density lipoprotein receptor-related protein 4 (LRP-4), also known as multiple epidermal growth ...
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