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Brian Nosek of University of Virginia and colleagues sought out to replicate 100 different studies, all published in 2008. [5] The project pulled these studies from three different journals, Psychological Science, the Journal of Personality and Social Psychology, and the Journal of Experimental Psychology: Learning, Memory, and Cognition, published in 2008 to see if they could get the same ...
If a finding was not replicated, then it failed to replicate with little variation across samples and contexts. This evidence is inconsistent with a proposed explanation that failures to replicate in psychology are likely due to changes in the sample between the original and replication study. [82]
In engineering, science, and statistics, replication is the process of repeating a study or experiment under the same or similar conditions to support the original claim, which is crucial to confirm the accuracy of results as well as for identifying and correcting the flaws in the original experiment. [1]
Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method.For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated.
Pseudoreplication was originally defined in 1984 by Stuart H. Hurlbert [2] as the use of inferential statistics to test for treatment effects with data from experiments where either treatments are not replicated (though samples may be) or replicates are not statistically independent.
In the biological sciences, replicates are an experimental units that are treated identically. Replicates are an essential component of experimental design because ...
The biological replicates include independent RNA extractions. Technical replicates may be two aliquots of the same extraction. Third, spots of each cDNA clone or oligonucleotide are present as replicates (at least duplicates) on the microarray slide, to provide a measure of technical precision in each hybridization.
Subsequent technological advances since the late 1990s have repeatedly transformed the field and made transcriptomics a widespread discipline in biological sciences. There are two key contemporary techniques in the field: microarrays , which quantify a set of predetermined sequences, and RNA-Seq , which uses high-throughput sequencing to record ...