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Pancytopenia is a medical condition in which there is significant reduction in the number of almost all blood cells (red blood cells, white blood cells, platelets, monocytes, lymphocytes, etc.). If only two parameters from the complete blood count are low, the term bicytopenia can be used.
Once pancytopenia develops, the prognosis is poor. Studies have shown 30% of CAMT patients die from bleeding complications, and another 20% die from complications related to hematopoietic stem cell transplantation. [3]
Laboratory findings include pancytopenia, marrow aplasia, abnormal liver enzymes, and electrolyte imbalance (when diarrhea is present). [citation needed] TA-GvHD can be suspected from a biopsy of the affected skin or liver, [4] and established by HLA analysis of the circulating lymphocytes. This testing can identify circulating lymphocytes with ...
If pancytopenia is present, bone marrow failure [4] must be considered and evaluation for bone marrow failure syndromes or aplastic anemia must be pursued. Treatment is dependent on the etiology and may include replacement of blood products as patients can develop severe anemia.
Hypersplenism and pancytopenia, the rapid and premature destruction of blood cells, leads to anemia, neutropenia, leukopenia, and thrombocytopenia (with an increased risk of infection and bleeding). Cirrhosis of the liver is rare. Severe pain associated with joints and bones occurs, frequently presenting in hips and knees.
Complications of Pregnancy, Childbirth, and the Puerperium XII 680–709: Diseases of the Skin and Subcutaneous Tissue XIII 710–739: Diseases of the Musculoskeletal System and Connective Tissue XIV 740–759: Congenital Anomalies XV 760–779: Certain Conditions originating in the Perinatal Period XVI 780–799: Symptoms, Signs and Ill ...
Hematologic manifestations related to bone marrow suppression and subsequent pancytopenia are a major source of morbidity and mortality. Additionally, extramedullary hematopoiesis can result in liver and spleen dysfunction. Cranial nerve dysfunction and neurologic complications are usually associated with infantile osteopetrosis.
Enlargement of the spleen is called splenomegaly, which also contributes to causing pancytopenia, particularly thrombocytopenia and anemia. Another complication of extramedullary hematopoiesis is poikilocytosis, or the presence of abnormally shaped red blood cells. [citation needed]