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  2. Cellular senescence - Wikipedia

    en.wikipedia.org/wiki/Cellular_senescence

    Cellular senescence is a phenomenon characterized by the cessation of cell division. [1] [2] [3] In their experiments during the early 1960s, ...

  3. Hayflick limit - Wikipedia

    en.wikipedia.org/wiki/Hayflick_limit

    The typical normal human fetal cell will divide between 50 and 70 times before experiencing senescence. As the cell divides, the telomeres on the ends of chromosomes shorten. The Hayflick limit is the limit on cell replication imposed by the shortening of telomeres with each division. This end stage is known as cellular senescence.

  4. Senescence - Wikipedia

    en.wikipedia.org/wiki/Senescence

    Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle.

  5. Senescence-associated secretory phenotype - Wikipedia

    en.wikipedia.org/wiki/Senescence-associated...

    Senescence and SASP can also occur in post-mitotic cells, notably neurons. [12] The SASP in senescent neurons can vary according to cell type, the initiator of senescence, and the stage of senescence. [12] An online SASP Atlas serves as a guide to the various types of SASP. [8]

  6. Hallmarks of aging - Wikipedia

    en.wikipedia.org/wiki/Hallmarks_of_aging

    Senescence can be induced by several factors, including telomere shortening, [37] DNA damage [38] and stress. Since the immune system is programmed to seek out and eliminate senescent cells, [39] it might be that senescence is one way for the body to rid itself of cells damaged beyond repair. The links between cell senescence and aging are several:

  7. Immortalised cell line - Wikipedia

    en.wikipedia.org/wiki/Immortalised_cell_line

    An immortalised cell line is a population of cells from a multicellular organism that would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cells can therefore be grown for prolonged periods in vitro. The mutations required for immortality can occur ...

  8. Judith Campisi - Wikipedia

    en.wikipedia.org/wiki/Judith_Campisi

    The two main pathways that control the senescence response in most cells are the p53 and p16-pRB tumor suppressor pathways. As a transcription regulator, the p53 protein activates the transcription factor p21, which results in the transcription of proteins that result in cellular senescence. Research has shown that the pathway is primarily ...

  9. G0 phase - Wikipedia

    en.wikipedia.org/wiki/G0_phase

    [5] [6] Senescence is distinct from quiescence because senescence is an irreversible state that cells enter in response to DNA damage or degradation that would make a cell's progeny nonviable. Such DNA damage can occur from telomere shortening over many cell divisions as well as reactive oxygen species (ROS) exposure, oncogene activation, and ...