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The Structural Classification of Proteins database [35] and CATH database [36] provide two different structural classifications of proteins. When the structural similarity is large the two proteins have possibly diverged from a common ancestor, [37] and shared structure between proteins is considered evidence of homology.
Protein Structure. Structural proteins confer stiffness and rigidity to otherwise-fluid biological components. Most structural proteins are fibrous proteins; for example, collagen and elastin are critical components of connective tissue such as cartilage, and keratin is found in hard or filamentous structures such as hair, nails, feathers ...
Collagen (/ ˈ k ɒ l ə dʒ ə n /) is the main structural protein in the extracellular matrix of the connective tissues of many animals. It is the most abundant protein in mammals, [1] making up 25% to 35% of protein content. Amino acids are bound together to form a triple helix of elongated fibril [2] known as a collagen helix.
The major force that keeps the coiled-coil structure is hydrophobic interactions between apolar residues along the keratin's helical segments. [21] Limited interior space is the reason why the triple helix of the (unrelated) structural protein collagen, found in skin, cartilage and bone, likewise has a high percentage of glycine.
Structural Classification of Proteins database (SCOP) [4] Both classification schemes are based on a hierarchy of fold types. At the top level are all alpha proteins (domains consisting of alpha helices), all beta proteins (domains consisting of beta sheets), and mixed alpha helix/beta sheet proteins.
Protein modules are a subset of protein domains which are found across a range of different proteins with a particularly versatile structure. Examples can be found among extracellular proteins associated with clotting, fibrinolysis, complement, the extracellular matrix, cell surface adhesion molecules and cytokine receptors. [35]
Pages in category "Structural proteins" The following 38 pages are in this category, out of 38 total. This list may not reflect recent changes. A. Actin nucleation core;
Collagen is the most abundant protein in the ECM, and is the most abundant protein in the human body. [17] [18] It accounts for 90% of bone matrix protein content. [19] Collagens are present in the ECM as fibrillar proteins and give structural support to resident cells.