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In the first line of defense, inhaled bacteria are trapped by mucus and are swept toward the pharynx and are swallowed. [1] Bacteria which penetrate the mucous layer are dealt with a second line of defense which includes antimicrobial peptides that are secreted by the surface epithelium of the respiratory tract which kill many strains of ...
Metabolic component: The third line of defense is slow, best measured by the base excess, [9] and mostly depends on the renal system which can add or remove bicarbonate ions (HCO − 3) to or from the ECF. [5] Bicarbonate ions are derived from metabolic carbon dioxide which is enzymatically converted to carbonic acid in the renal tubular cells.
Complement proteins are proteins that play a role in the non-specific immune responses alongside these non-specific immune cells to make up the first line of immune defense. [4] The non-specific immune response is an immediate antigen-independent response, however it is not antigen-specific. Non-specific immunity results in no immunologic memory.
A scanning electron microscope image of a single neutrophil (yellow/right), engulfing anthrax bacteria (orange/left) – scale bar is 5 μm (false color). The immune system is a network of biological systems that protects an organism from diseases.
The glia limitans also acts as a second line of defense against anything that passes the blood–brain barrier. However, because the astrocytes surrounding the vessels are connected by gap junctions, it is not considered part of the BBB and material can readily pass between the foot processes.
An immune response is a physiological reaction which occurs within an organism in the context of inflammation for the purpose of defending against exogenous factors. These include a wide variety of different toxins, viruses, intra- and extracellular bacteria, protozoa, helminths, and fungi which could cause serious problems to the health of the host organism if not cleared from the body.
[38] [39] Thanatosis is used as a second line of defence when detected by a potential predator and is commonly observed within the Dyspnoi and Laniatores suborders, [36] with individuals becoming rigid with legs either retracted or stretched. [40] [41] [42] [43]
XthA (exonuclease III, a DNA repair enzyme) and KatE (catalase) are known to play important roles in the defense against oxidative stress but KatF regulon genes are not induced by oxidative stress. [2] There is an overlap between oxidative stress response and other regulatory networks like heat shock response, SOS response.