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It is composed of around 270 bones at birth – this total decreases to around 206 bones by adulthood after some bones get fused together. [1] The bone mass in the skeleton makes up about 14% of the total body weight (ca. 10–11 kg for an average person) and reaches maximum mass between the ages of 25 and 30. [ 2 ]
The human musculoskeletal system is made up of the bones of the skeleton, muscles, cartilage, [1] tendons, ligaments, joints, and other connective tissue that supports and binds tissues and organs together. The musculoskeletal system's primary functions include supporting the body, allowing motion, and protecting vital organs. [2]
It is composed of 270 bones at the time of birth, [2] but later decreases to 206: 80 bones in the axial skeleton and 126 bones in the appendicular skeleton. 172 of 206 bones are part of a pair and the remaining 34 are unpaired. [3] Many small accessory bones, such as sesamoid bones, are not included in this.
Bone tissue is a dynamic system with active metabolism. [24] Bone tissue remodelling or bone remodeling is a successive chain of old bone matrix removal and its replacement with a new one. [25] These processes make a child’s skeleton grow and extend, while childhood is characterized by bone tissue growth rather than its resorption.
In the human body at birth, approximately 300 bones are present. Many of these fuse together during development, leaving a total of 206 separate bones in the adult, not counting numerous small sesamoid bones. [3] [4] The largest bone in the body is the femur or thigh-bone, and the smallest is the stapes in the middle ear.
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
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The human skeletal system is a complex organ in constant equilibrium with the rest of the body. In addition to supporting and giving structure to the body, a bone is the major reservoir for many minerals and compounds essential for maintaining a healthy pH balance. [5]