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LATE is a term that describes a prevalent medical condition with impaired memory and thinking in advanced age, often culminating in the dementia clinical syndrome. [1] In other words, the symptoms of LATE are similar to those of Alzheimer's disease. The acronym LATE stands for Limbic-predominant Age-related TDP-43 Encephalopathy.
Mild dementia symptoms mimic episodes of age-related forgetfulness. Moderate or middle-stage dementia (stages 4 and 5). Moderate dementia symptoms significantly affect a person’s personality and ...
As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and behavioral issues. [2] As a person's condition declines, they often withdraw from family and society. [16] Gradually, bodily functions are lost, ultimately leading to death.
In some cases, this results from the belief that the martyr has been singled out for persecution because of exceptional ability or integrity. [1] Other martyr complexes involve willful suffering in the name of love or duty. This has been observed especially in poor families, as well as in codependent or abusive relationships.
Childhood dementia is very often diagnosed late, misdiagnosed, or not diagnosed at all. [9] A correct diagnosis happens, on average, 2 years or more after symptoms become apparent. Additionally, children affected by childhood dementia are often misdiagnosed with: Autism [16] [9] [17] Developmental or intellectual delay [16] [9] ADHD [9] Others [9]
Terminal illness or end-stage disease is a disease that cannot be cured or adequately treated and is expected to result in the death of the patient. This term is more commonly used for progressive diseases such as cancer, dementia, advanced heart disease, and for HIV/AIDS, or long COVID in bad cases, rather than for injury.
Diagnosis of mixed dementia can be difficult, as often only one type will predominate. This makes the treatment of people with mixed dementia uncommon, with many people missing out on potentially helpful treatments. Mixed dementia can mean that symptoms onset earlier, and worsen more quickly since more parts of the brain will be affected. [15]
General paresis, also known as general paralysis of the insane (GPI), paralytic dementia, or syphilitic paresis is a severe neuropsychiatric disorder, classified as an organic mental disorder, and is caused by late-stage syphilis and the chronic meningoencephalitis and cerebral atrophy that are associated with this late stage of the disease when left untreated.