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Neostigmine, sold under the brand name Bloxiverz, among others, is a medication used to treat myasthenia gravis, Ogilvie syndrome, and urinary retention without the presence of a blockage. [ 3 ] [ 4 ] It is also used in anaesthesia to end the effects of non-depolarising neuromuscular blocking medication . [ 3 ]
If nicotinic receptors of the autonomic ganglia or adrenal medulla are blocked, these drugs may cause autonomic symptoms. Also, neuromuscular blockers may facilitate histamine release, which causes hypotension, flushing, and tachycardia. Succinylcholine may also trigger malignant hyperthermia in rare cases in patients who may be susceptible.
Relaxation of ciliary muscle causes paralysis of accommodation (cycloplegia) and impaired near vision; Raised intraocular pressure; Gastrointestinal tract: Inhibition of motility; Other smooth muscle Relaxation of bronchial smooth muscle; Biliary and urinary tract smooth muscle only slightly affected, might precipitate urinary retention
As a result of cholinergic crisis, the muscles stop responding to the high synaptic levels of ACh, leading to flaccid paralysis, respiratory failure, and other signs and symptoms reminiscent of organophosphate poisoning.
Anticholinergic drugs are used to treat a variety of conditions: Dizziness (including vertigo and motion sickness-related symptoms); Extrapyramidal symptoms, a potential side-effect of antipsychotic medications
With an estimated 52.5 million adults in the U.S. affected by arthritis alone and up to 24% of adults experiencing muscle pain during their lifetime, effective topical pain relievers can be life ...
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