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Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]
The monitoring of warfarin and keeping the international normalized ratio (INR) between 2.0 and 3.0, along with avoiding over and under treatment, has driven a search for an alternative. [3] [14] A naturally occurring inhibitor of factor Xa was reported in 1971 by Spellman et al. from the dog hookworm. [15]
Rivaroxaban (Xarelto) was the first approved FXa inhibitor to become commercially available in Europe and Canada in 2008. [1] The second one was apixaban (Eliquis), approved in Europe in 2011 [2] and in the United States in 2012. [3] The third one edoxaban (Lixiana, Savaysa) was approved in Japan in 2011 and in Europe and the US in 2015. [4]
Warnings - covers possible serious side effects that may occur (e.g., boxed warning) Precautions - explains how to use the medication safely including physical impairments, food (grapefruits) and drug interactions; for example "Do not drink alcohol while taking this medication" or "Do not take this medication if you are currently taking MAOI ...
Pistons G Jaden Ivey undergoes surgery to repair broken fibula after collision with Cole Anthony
The new $2.3 billion taxpayer-funded Nissan Stadium is expected to open in 2027, but the NFL is asking for $80,000 in upgrades for the current one, according to the report.
The main goal of diabetes management is to keep blood glucose (BG) levels as normal as possible. [1] If diabetes is not well controlled, further challenges to health may occur. [1] People with diabetes can measure blood sugar by various methods, such as with a BG meter or a continuous glucose monitor, which monitors over several days. [2]
A young dog is making a fresh start ahead of the new year.. Armando — a 4-year-old Labrador retriever mix — has found his forever home after being abandoned with a note in Arizona earlier this ...
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