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Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B 1). [1] A severe and chronic form is known as beriberi. [1] [7] The name beriberi was possibly borrowed in the 18th century from the Sinhalese phrase බැරි බැරි (bæri bæri, “I cannot, I cannot”), owing to the weakness caused by the condition.
Because thiamine deficiency causes problems with memory and other cognitive functions, thiamine and analogs like sulbutiamine have been studied in clinical trials in the 1980s and 1990s for age-associated cognitive decline. [10] Sulbutiamine has been explored in clinical trials as a potential treatment for chronic fatigue syndrome (CFS). [6]
Fursultiamine (INN; chemical name thiamine tetrahydrofurfuryl disulfide or TTFD; brand names Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor, Lipothiamine) is a medication and vitamin used to treat thiamine deficiency. Chemically, it is a disulfide derivative of thiamine and is similar in structure to allithiamine. [1]
Vitamin B 1 analogues are analogues of vitamin B 1, thiamine. They typically have improved bioavailability relative to thiamine itself, and are used to treat conditions caused by vitamin B 1 deficiency. These conditions include beriberi, Korsakoff's syndrome, Wernicke's encephalopathy and diabetic neuropathy.
Prosultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B 1 deficiency .
Vitamin B12 deficiency symptoms . Vitamin B12 deficiency has a few hallmark symptoms, according to doctors: Lack of energy. Mental fatigue. Nausea, vomiting, or diarrhea. Lack of appetite. Weight loss
Calcium and magnesium have been shown to affect the distribution of thiamine in the body and magnesium deficiency has been shown to aggravate thiamine deficiency. [22] Thiamine contents in human tissues are less than those of other species. [16] [64] The half-life of thiamine content stored in human body is about 9-18 days. [62]
Hamm took a drug test that weekend, knowing he would fail. A week later, he delivered himself to his probation officer and soon after he was booked into the Campbell County jail. But before that, he had called Greenwell, Grateful Life’s intake supervisor. Hamm had begged to be allowed back into the program. Greenwell had turned him down.