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This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil. Thus, the metabolite is responsible for about 20% of sildenafil's action. Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).
Whether you’re one of the 30 million men who have (ED) or not, you’ve almost certainly heard of Viagra. Maybe you even know about other ED medications, like Levitra or Stendra or Cialis, too.
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Its long duration means side effects could last longer than with other ED pills. Tadalafil Pros Tadalafil has a half-life of 17.5 hours — it remains active in your body for far longer than other ...
Likewise, Viagra shouldn’t be combined with antiretroviral drugs used to treat HIV/AIDS, as it can cause an increased concentration of sildenafil in the body. Breastfeeding women shouldn’t ...
When to Take Viagra: 30-60 Minutes Before Intimacy, Not Earlier. If you’re planning to have intimacy, it’s best to take your recommended dose of Viagra ahead of time.
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