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Mirtazapine is sometimes described as a noradrenergic and specific serotonergic antidepressant (NaSSA), [11] although the actual evidence in support of this label has been regarded as poor. [17] It is a tetracyclic piperazine-azepine. [85] Mirtazapine has antihistamine, α 2-blocker, and antiserotonergic activity.
Delirium (formerly acute confusional state, an ambiguous term which is now discouraged) [1] is a specific state of acute confusion attributable to the direct physiological consequence of a medical condition, effects of a psychoactive substance, or multiple causes, which usually develops over the course of hours to days.
It has also been suggested that mirtazapine has no significant serotonergic effects and is therefore not a dual action drug. [34] Bupropion has also been suggested to cause SS, [35] [36] although as there is no evidence that it has any significant serotonergic activity, it is thought unlikely to produce the syndrome. [37]
Chemical structure of the prototypical NaSSA mirtazapine (original brand name Remeron). Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1]
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Tricyclics and SSRI can cause the so-called drug-induced QT prolongation, especially in older adults; [131] this condition can degenerate into a specific type of abnormal heart rhythm called Torsades de points, which can potentially lead to sudden cardiac arrest. [132] Some antidepressants are also believed to increase thoughts of suicidal ...
If you’re stuck on today’s Wordle answer, we’re here to help—but beware of spoilers for Wordle 1270 ahead. Let's start with a few hints.
Statins are generally recommended for adults between the ages of 40 and 75 who have heart disease risk factors. Despite having higher risks for cardiovascular disease, fewer older adults use statins.
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