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  2. Rapidly progressive glomerulonephritis - Wikipedia

    en.wikipedia.org/wiki/Rapidly_progressive...

    Characterized by deposition of immune complexes in glomerular tissues, type II RPGN accounts for 40 [11] % of cases. Any immune complex disease—including systemic lupus erythematosus, acute proliferative glomerulonephritis, Henoch–Schönlein purpura, and IgA nephropathy—that involves the glomerulus may progress to RPGN if severe enough. [2]

  3. Pauci-immune - Wikipedia

    en.wikipedia.org/wiki/Pauci-immune

    When these are subjected to immunofluorescence, three patterns can be observed: linear, granular and negative (pauci-immune). [1] The linear and granular patterns are examples of positive immunofluorescence that are associated as follows: Goodpasture syndrome (linear pattern), post-streptococcal glomerulonephritis (granular), and diffuse ...

  4. Microscopic polyangiitis - Wikipedia

    en.wikipedia.org/wiki/Microscopic_polyangiitis

    Immunsuppressive treatment is the gold standard management in order to achieve remission of the blood vessel inflammation that occurs in active microscopic polyangitis. The current immunosuppressive protocols consists of a combination of high dose of glucocorticoids in combination with either cyclophosphamide or Rituximab . [ 8 ]

  5. Glomerulonephritis - Wikipedia

    en.wikipedia.org/wiki/Glomerulonephritis

    As the glomerulonephritis progresses, the tubules of the kidney become infected, leading to atrophy and hyalinisation. The kidney appears to shrink. Treatment with corticosteroids is attempted if the disease progresses. [citation needed] In extremely rare cases, the disease has been known to run in families, usually passed down through the females.

  6. Diffuse proliferative nephritis - Wikipedia

    en.wikipedia.org/wiki/Diffuse_proliferative...

    In 2014 a study was completed to diagnose glomerulonephritis based on etiology. Using immunofluorescence and light microscopy, the investigators were determining the classification for the disease based on if the disease was immune complex mediated, pauci- immune, or complement mediated.

  7. Anti-neutrophil cytoplasmic antibody - Wikipedia

    en.wikipedia.org/wiki/Anti-neutrophil_cytoplasm...

    [5] [6] PR3 directed c-ANCA is present in 80-90% of granulomatosis with polyangiitis, 20-40% of microscopic polyangiitis, 20-40% of pauci-immune crescentic glomerulonephritis and 35% of eosinophilic granulomatosis with polyangiitis. c-ANCA (atypical) is present in 80% of cystic fibrosis (with BPI as the target antigen) and also in inflammatory ...

  8. Ronald J. Falk - Wikipedia

    en.wikipedia.org/wiki/Ronald_J._Falk

    Over the ensuing decade, Falk and his colleagues have more fully documented the pathogenicity of ANCA. In 2002, they demonstrated in a mouse model that passively transferred anti-myeloperoxidase antibodies were capable of inducing pauci-immune necrotizing and crescentic glomerulonephritis. [9]

  9. Goodpasture syndrome - Wikipedia

    en.wikipedia.org/wiki/Goodpasture_syndrome

    Goodpasture syndrome (GPS), also known as anti–glomerular basement membrane disease, is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs, glomerulonephritis, [1] and kidney failure. [2]