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  2. Allele - Wikipedia

    en.wikipedia.org/wiki/Allele

    An allele [1], or allelomorph, is a variant of the sequence of nucleotides at a particular location, or locus, on a DNA molecule. [2]Alleles can differ at a single position through single nucleotide polymorphisms (SNP), [3] but they can also have insertions and deletions of up to several thousand base pairs.

  3. Haplotype - Wikipedia

    en.wikipedia.org/wiki/Haplotype

    An organism's genotype may not define its haplotype uniquely. For example, consider a diploid organism and two bi-allelic loci (such as SNPs) on the same chromosome. Assume the first locus has alleles A or T and the second locus G or C. Both loci, then, have three possible genotypes: (AA, AT, and TT) and (GG, GC, and CC), respectively.

  4. Allele frequency - Wikipedia

    en.wikipedia.org/wiki/Allele_frequency

    Allele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a fraction or percentage. [1]

  5. Locus (genetics) - Wikipedia

    en.wikipedia.org/wiki/Locus_(genetics)

    Genes may possess multiple variants known as alleles, and an allele may also be said to reside at a particular locus. Diploid and polyploid cells whose chromosomes have the same allele at a given locus are called homozygous with respect to that locus, while those that have different alleles at a given locus are called heterozygous. [3]

  6. Gene - Wikipedia

    en.wikipedia.org/wiki/Gene

    Alleles at a locus may be dominant or recessive; dominant alleles give rise to their corresponding phenotypes when paired with any other allele for the same trait, whereas recessive alleles give rise to their corresponding phenotype only when paired with another copy of the same allele. If you know the genotypes of the organisms, you can ...

  7. Haploinsufficiency - Wikipedia

    en.wikipedia.org/wiki/Haploinsufficiency

    Haploinsufficiency is the standard explanation for dominant deleterious alleles. [ clarification needed ] In the alternative case of haplosufficiency , the loss-of-function allele behaves as above, but the single standard allele in the heterozygous genotype produces sufficient gene product to produce the same, standard phenotype as seen in the ...

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  9. Fixed allele - Wikipedia

    en.wikipedia.org/wiki/Fixed_allele

    Fixed alleles were first defined by Motoo Kimura in 1962. [5] Kimura discussed how fixed alleles could arise within populations and was the first to generalize the topic. He credits the works of Haldane in 1927 [ 6 ] and Fisher in 1922 [ 7 ] as being important in providing foundational information that allowed him to come to his conclusion.