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Variant angina, also known as Prinzmetal angina, vasospastic angina, angina inversa, coronary vessel spasm, or coronary artery vasospasm, [2] is a syndrome typically consisting of angina (cardiac chest pain).
Coronary vasospasm classically produces chest pain at rest, also known as variant angina (vasospastic angina or Prinzmetal's angina). [5] Chest pain is more common at certain times of the day, usually from late night to early morning. [6] These episodes can be accompanied by nausea, vomiting, cold sweating, and even syncope.
Vasospasm is the major cause of Prinzmetal's angina. Cerebral vasospasm may arise in the context of subarachnoid hemorrhage as symptomatic vasospasm (or delayed cerebral ischemia), where it is a major contributor to post-operative stroke and mortality. Vasospasm typically appears 4 to 10 days after subarachnoid hemorrhage, however the ...
Myron Prinzmetal (February 8, 1908 – January 8, 1987) was an American cardiologist. He studied hypertension and heart arrhythmias among many other topics, and was the first to describe Prinzmetal angina .
A variant form of angina—Prinzmetal's angina—occurs in patients with normal coronary arteries or insignificant atherosclerosis. It is believed caused by spasms of the artery. It occurs more in younger women. [23] Coital angina, also known as angina d'amour, is angina subsequent to sexual intercourse. [24]
Now a third type of angina is vasospastic angina, also known as prinzmetal angina, and patients may or may not also have atherosclerosis. Ischemia, and resulting chest pain is due to coronary artery vasospasms, meaning the smooth muscles around the arteries constrict extremely tightly and reduce blood flow enough to cause ischemia.
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The Kounis syndrome is distinguished from two other causes of coronary artery spasms and symptoms viz., the far more common, non-allergic syndrome, Prinzmetal's angina [4] and eosinophilic coronary periarteritis, an extremely rare disorder caused by extensive eosinophilic infiltration of the adventitia and periadventitia, i.e. the soft tissues ...