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Central obesity is a symptom of Cushing's syndrome [38] and is also common in patients with polycystic ovary syndrome (PCOS). Central obesity is associated with glucose intolerance and dyslipidemia. Once dyslipidemia becomes a severe problem, an individual's abdominal cavity would generate elevated free fatty acid flux to the liver.
A high ABSI appears to correspond to a higher proportion of central obesity, or abdominal fat. In a sample of Americans in the National Health and Nutrition Examination Survey , death rates in some subjects were high for both high and low BMI and WC, a familiar conundrum associated with BMI. [ 6 ]
More than twenty-five years ago, WHtR was first suggested as a simple health risk assessment tool because "it is a proxy for harmful central adiposity"; [3] it predicts obesity-related cardiovascular disease. A boundary value of 0.5 was proposed to indicate increased risk.
Central obesity is a key feature of the syndrome, as both a sign and a cause, in that the increasing adiposity often reflected in high waist circumference may both result from and contribute to insulin resistance. However, despite the importance of obesity, affected people who are of normal weight may also be insulin-resistant and have the ...
The widely used body mass index (BMI) provides a measure that allows the comparison of the adiposity of individuals of different heights and weights. While BMI largely increases as adiposity increases, due to differences in body composition, other indicators of body fat give more accurate results; for example, individuals with greater muscle ...
Obesity has been observed throughout human history. Many early depictions of the human form in art and sculpture appear obese. [2] However, it was not until the 20th century that obesity became common — so much so that, in 1997, the World Health Organization (WHO) formally recognized obesity as a global epidemic [3] and estimated that the worldwide prevalence of obesity has nearly tripled ...
In the European Union waist circumference of ≥ 94 cm(≈37") in men and ≥ 80 cm(≈31.5") in non pregnant women are used as cut offs for central obesity. [28] A lower cut off of 90 cm has been recommended for South Asian and Chinese men, while a cut off of 85 cm has been recommended for Japanese men. [28]
Adipose tissue (also known as body fat or simply fat) is a loose connective tissue composed mostly of adipocytes. [1] [2] It also contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular endothelial cells and a variety of immune cells such as adipose tissue macrophages.