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HER2 is the target of the monoclonal antibody trastuzumab (marketed as Herceptin). Trastuzumab is effective only in cancers where HER2 is over-expressed. One year of trastuzumab therapy is recommended for all patients with HER2-positive breast cancer who are also receiving chemotherapy. [33] Twelve months of trastuzumab therapy is optimal.
This is an accepted version of this page This is the latest accepted revision, reviewed on 20 December 2024. Cancer that originates in mammary glands Medical condition Breast cancer An illustration of breast cancer Specialty Oncology Symptoms A lump in a breast, a change in breast shape, dimpling of the skin, fluid from the nipple, a newly inverted nipple, a red scaly patch of skin on the ...
ER-positive is one of the Receptor statuses identified in the classification of breast cancer.Receptor status was traditionally considered by reviewing each individual receptor (ER, PR, her2) in turn, but newer approaches look at these together, along with the tumor grade, to categorize breast cancer into several conceptual molecular classes [1] that have different prognoses [2] and may have ...
When a tumor is “triple positive,” that means that its growth is fueled by both estrogen and progesterone hormones, as well as a protein called human epidermal growth factor receptor 2 (HER2 ...
Luminal B breast cancer is estrogen receptor-positive, which means the cancer cells rely on estrogen to grow. ... HER2 is the protein that helps breast cancer cells grow, ...
Although herceptin works well in most breast cancer cases, it has not been yet elucidated as to why some HER2-positive breast cancers don't respond well. Research suggests that a low FISH test ratio in estrogen receptor positive breast cancers are less likely to respond to this drug. [33]
This is a list of major breast cancer cell lines that are primarily used in breast cancer research. [Notes 1] List of cell lines. Cell line Primary tumor
The film premiered on October 18, 2008, for Lifetime's "Stop Breast Cancer for Life" public service and advocacy campaign, during the National Breast Cancer Awareness Month. [ 8 ] [ 9 ] The movie averaged 2.5 million viewers in its debut on October 18, 2008.
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