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Gemcitabine, sold under the brand name Gemzar, among others, [1] is a chemotherapy medication used to treat cancers. [2] It is used to treat testicular cancer , [ 3 ] breast cancer , ovarian cancer , non-small cell lung cancer , pancreatic cancer , and bladder cancer .
In the United Kingdom, the National Institute for Health and Care Excellence (NICE), in a draft guidance issued in 2014, rejected the use of Abraxane in treatment due to concerns of side effects, efficacy, and cost relative to Gemzar (gemcitabine). [10] However, on 18 May 2017 NICE issued a reappraisal for the use of Abraxane in the UK.
Participants were required to have received at least one prior gemcitabine-containing regimen in the advanced disease setting. [ 2 ] The US Food and Drug Administration (FDA) granted the application for zanidatamab priority review , breakthrough therapy , and orphan drug designations.
Taking medications like blood pressure and lipid-lowering drugs for more than 5 years is associated with a lower incidence of dementia, a new study has found.
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In a one-year, Phase II Avicine cancer vaccine study, a group of patients were treated with Avicine alongside the combination of Gemcitabine (Gemzar), [2] the results yielding that Avicine could be induced alongside Gemzar, in the prostate region. As the 3rd and 4th clinical trials were not done this was never done as a commercial treatment. [1]
Because they have different dose-limiting adverse effects, they can be given together at full doses in chemotherapy regimens. [1] The first successful combination chemotherapy was MOPP, introduced in 1963 for lymphomas. The term "induction regimen" refers to a chemotherapy regimen used for the initial treatment of a disease.
Examples: 5-Fluorouracil, Gemcitabine, and Cytarabine; nucleoside analogues – nucleoside alternatives that consist of a nucleic acid analogue and a sugar. This means these are the same bases as above, but with an added sugar group. For the nucleoside analogues either the base or the sugar component can be altered.