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Atomoxetine is sometimes used in the treatment of cognitive impairment and frontal lobe symptoms due to conditions like traumatic brain injury (TBI). [47] [48] It is used to treat ADHD-like symptoms such as sustained attentional problems, disinhibition, [49] lack of arousal, fatigue, and depression, including symptoms from cognitive disengagement syndrome. [47]
This was from the notion that depression was primarily due to norepinephrine deficits, partly based on the fact that drugs that relieve depression increase brain norepinephrine levels. [28] To date, a great number of potent and selective and mixed norepinephrine reuptake inhibitors (NRIs) have been marketed as antidepressants. [11]
The effects of DAT KO in animal models of depression are larger than those produced by NET or SERT KO, and unlikely to be simply the result of the confounding effects of locomotor hyperactivity; thus, these data support reevaluation of the role that DAT expression could play in depression and the potential antidepressant effects of DAT blockade.
More specifically, it looked at the effect of methylphenidate (brand names Ritalin, Concerta), a stimulant, and atomoxetine (Strattera), a non-stimulant, on the brain.
Drugs that selectively block the reuptake of serotonin and norepinephrine effectively treat depression and are better tolerated than TCAs. TCAs have comprehensive effects on various neurotransmitters receptors, which leads to lack of tolerability and increased risk of toxicity. [2]
Dizziness is a short-term side effect of sertraline that usually doesn’t persist for longer than two to four weeks (and sometimes even less), but if you notice that frequent dizziness or ...
The latter review, also examined the efficacy of reboxetine as a function of baseline depression, and concluded that it was effective in severe depression and panic disorder but did not show effects significantly superior to placebo in mild depression. [5] A closely related type of drug is a norepinephrine releasing agent (NRA).
“Insulin is critical to brain function,” says Beeri. ... that GLP-1s might reduce depression symptoms and suicidal thoughts. However, some users have also reported increases in depression ...
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