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AP-1 was first discovered as a TPA-activated transcription factor that bound to a cis-regulatory element of the human metallothionein IIa promoter and SV40. [3] The AP-1 binding site was identified as the 12-O-Tetradecanoylphorbol-13-acetate response element (TRE) with the consensus sequence 5’-TGA G/C TCA-3’. [4]
Download as PDF; Printable version; In other projects Wikidata item; ... AP1 or AP-1 may refer to: Biology. Activator protein 1, dimeric transcription factor;
Download as PDF; Printable version; In other projects Wikidata item; Appearance. move to sidebar hide The AP-1 binding site, also known as the AP-1 promoter site ...
1174 11769 Ensembl ENSG00000106367 ENSMUSG00000004849 UniProt P61966 P61967 RefSeq (mRNA) NM_057089 NM_001283 NM_007457 RefSeq (protein) NP_001274 NP_031483 Location (UCSC) Chr 7: 101.15 – 101.16 Mb Chr 5: 137.06 – 137.07 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. Function The protein ...
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The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles.
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Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor ...