Search results
Results from the WOW.Com Content Network
Iron in ferritin or hemosiderin can be extracted for release by the RE cells, although hemosiderin is less readily available. Under steady-state conditions, the level of ferritin in the blood serum correlates with total body stores of iron; thus, the serum ferritin FR5Rl is the most convenient laboratory test to estimate iron stores.
Hemosiderinuria (syn. haemosiderinuria) is the presence of hemosiderin in urine. [1] It is often the result of chronic intravascular hemolysis, in which hemoglobin is released from red blood cells into the bloodstream in excess of the binding capacity of haptoglobin. The function of haptoglobin is to bind to circulating hemoglobin, thereby ...
Hemosiderin is also generated from the abnormal metabolic pathway of ferritin. [3] It is only found within cells (as opposed to circulating in blood) and appears to be a complex of ferritin, denatured ferritin and other material. [4] [5] The iron within deposits of hemosiderin is very poorly available to supply iron when needed.
Urinalysis, a portmanteau of the words urine and analysis, [1] is a panel of medical tests that includes physical (macroscopic) examination of the urine, chemical evaluation using urine test strips, and microscopic examination.
Ferritin is an iron reservoir for an individual cell. It is found in all cells types and localized in the cytosol. Ferritin is a large protein composed of 24 subunits surrounding a core full of iron atoms. It is capable of holding 0-4500 iron atoms, [19] which can be used as a reservoir for cellular needs.
Urine typically has a mild odor, but strong or unusual smells can indicate a problem. A strong ammonia scent could suggest dehydration. A foul or unusual smell could be a sign of a urinary tract ...
In urine cytology, collected urine is examined microscopically. One limitation, however, is the inability to definitively identify low-grade cancer cells and urine cytology is used mostly to identify high-grade tumors. [4] If the test detects atypical or cancerous cells, further tests may be recommended, such as cystoscopy and a CT scan.
These intestinal lining cells can then either store the iron as ferritin, which is accomplished by Fe 2+ binding to apoferritin (in which case the iron will leave the body when the cell dies and is sloughed off into feces), or the cell can release it into the body via the only known iron exporter in mammals, ferroportin.