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There are several factors that put people at higher risk of contracting type 2 diabetes. Among these are obesity, lack of exercise, and aging. But, not everyone that becomes diabetic falls under these categories. However, what has become clear is that there are multiple loci which increase a person's susceptibility to Type 2 diabetes.
Chronic hyperglycemia (high blood sugar) injures the heart in patients without a history of heart disease or diabetes and is strongly associated with heart attacks and death in subjects with no coronary heart disease or history of heart failure. [22] Also, a life-threatening consequence of hyperglycemia can be nonketotic hyperosmolar syndrome. [16]
Type 2 diabetes (T2D), formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. [6] Common symptoms include increased thirst , frequent urination , fatigue and unexplained weight loss . [ 3 ]
Obesity has been found to contribute to approximately 55% of cases of type 2 diabetes; [10] chronic obesity leads to increased insulin resistance that can develop into type 2 diabetes, [11] most likely because adipose tissue (especially that in the abdomen around internal organs) is a source of several chemical signals, hormones and cytokines, to other tissues.
Most cases of type 2 diabetes involved many genes contributing small amount to the overall condition. [1] As of 2011 more than 36 genes have been found that contribute to the risk of type 2 diabetes. [2] All of these genes together still only account for 10% of the total genetic component of the disease. [2]
The main risk factor is a history of diabetes mellitus type 2. [4] Occasionally it may occur in those without a prior history of diabetes or those with diabetes mellitus type 1. [3] [4] Triggers include infections, stroke, trauma, certain medications, and heart attacks. [4] Other risk factors: Lack of sufficient insulin (but enough to prevent ...
What’s more, “chronic glucose elevations” can increase one’s risk of developing Type 2 diabetes, Warshaw says, whereas normal, digestion-related blood sugar spikes do not.
Gestational diabetes is a condition in which a woman without diabetes develops high blood sugar levels during pregnancy. [4] Type 2 diabetes mellitus and prediabetes are associated with changes in levels of metabolic markers, these markers could serve as potential prognostic or therapeutic targets for patients with prediabetes or Type 2 ...
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