Ads
related to: drugs that increase glutamate activity in the brain naturally
Search results
Results from the WOW.Com Content Network
Glutamatergic means "related to glutamate". A glutamatergic agent (or drug ) is a chemical that directly modulates the excitatory amino acid ( glutamate / aspartate ) system in the body or brain. Examples include excitatory amino acid receptor agonists , excitatory amino acid receptor antagonists , and excitatory amino acid reuptake inhibitors .
NMDA receptors are glutamate-gated cation channels that allow for an increase of calcium permeability. Channel activation of NMDA receptors is a result of the binding of two co agonists, glycine and glutamate .
A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to increased extracellular concentrations of GABA and therefore an increase in GABAergic neurotransmission. [1]
Glutamate is a very major constituent of a wide variety of proteins; consequently it is one of the most abundant amino acids in the human body. [1] Glutamate is formally classified as a non-essential amino acid, because it can be synthesized (in sufficient quantities for health) from α-ketoglutaric acid, which is produced as part of the citric acid cycle by a series of reactions whose ...
A stimulant is an overarching term that covers many drugs including those that increase the activity of the central nervous system and the body, [5] drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects. [6] Sympathomimetic effects are those effects that mimic or copy the actions of the sympathetic nervous ...
GLP-1 drugs may protect the brain from inflammation, some studies say, but others warn they may increase depression risk. Image credit: James Manning – PA Images/Getty Images.
In some cases the level or exposure-time may be critical, with some substances only becoming neurotoxic in certain doses or time periods. Some of the most common naturally occurring brain toxins that lead to neurotoxicity as a result of long term drug use are amyloid beta (Aβ), glutamate, dopamine, and oxygen radicals.
Failure to manage the alcohol withdrawal syndrome appropriately can lead to permanent brain damage or death. [11] Acamprosate, a drug used to promote abstinence from alcohol, an NMDA antagonist drug, reduces excessive glutamate activity in the central nervous system and thereby may reduce excitotoxicity and withdrawal related brain damage. [12 ...
Ads
related to: drugs that increase glutamate activity in the brain naturally