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These factors interact to create a threshold for the development of mental disorders. The types of coping and defense mechanisms used can either contribute to vulnerability or act as protective factors. [37] Coping and defence mechanisms work in tandem to balance out feelings of anxiety or guilt, categorizing them both as a "mechanisms of ...
Most current researchers have agreed that isolation is one of the most effective and important mechanisms of defense from harmful cognitions. [1] It is a coping mechanism that does not require delusions of reality, which makes it more plausible than some alternatives (denial, sublimation, projection, etc.). Further research will be needed for ...
This has provided key insights on the underlying mechanisms of addiction, including substance use and non-substance (behavioral) addictions. [15] Addiction hijacks the brain’s reward system, which normally encourages individuals to engage in survival-related activities such as socializing, eating, or achieving goals. Substances or specific ...
The common biomolecular mechanisms underlying addiction – CREB and ΔFosB – were reviewed by Eric J. Nestler in a 2013 review. [3] Genetics and mental disorders may precipitate the severity of a drug addiction. It is estimated that 50% of healthy individuals developing an addiction can trace the cause to genetic factors. [4]
Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption ...
The underlying mechanism involves a decreased responsiveness of GABA receptors in the brain. [3] The withdrawal process is typically followed using the Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-Ar). [3] The typical treatment of alcohol withdrawal is with benzodiazepines such as chlordiazepoxide or diazepam. [2]
Helping an individual stop using drugs is not enough. Addiction treatment must also help the individual maintain a drug-free lifestyle, and achieve productive functioning in the family, at work, and in society. Addiction is a disease which alters the structure and function of the brain.
Neuroscientists studying addiction define relapse as the reinstatement of drug-seeking behavior after a period of abstinence. The structural changes in the VTA are hypothesized to contribute to relapse. [47] As the molecular mechanisms of relapse are better understood, pharmacological treatments to prevent relapse are further refined. [48]