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Photolabile protecting groups bear a chromophore, which is activated through radiation with an appropriate wavelength and so can be removed. [6] For examples the o-nitrobenzylgroup ought be listed here. The rare double-layer protecting group is a protected protecting group, which exemplify high stability.
Generic structure of acetals. In organic chemistry, an acetal is a functional group with the connectivity R 2 C(OR') 2.Here, the R groups can be organic fragments (a carbon atom, with arbitrary other atoms attached to that) or hydrogen, while the R' groups must be organic fragments not hydrogen.
In carbohydrate chemistry carbohydrate acetalisation is an organic reaction and a very effective means of providing a protecting group. The example below depicts the acetalisation reaction of D-ribose 1. With acetone or 2,2-dimethoxypropane as the acetalisation reagent the reaction is under thermodynamic reaction control and results in the ...
Acetals, as already pointed out, are stable tetrahedral intermediates so they can be used as protective groups in organic synthesis. Acetals are stable under basic conditions, so they can be used to protect ketones from a base. The acetal group is hydrolyzed under acidic conditions. An example with a dioxolane protecting group is given below.
General structure of a monothioacetal General structure of a dithioacetal. In organosulfur chemistry, thioacetals are the sulfur analogues of acetals (R−CH(−OR) 2).There are two classes: the less-common monothioacetals, with the formula R−CH(−OR')−SR", and the dithioacetals, with the formula R−CH(−SR') 2 (symmetric dithioacetals) or R−CH(−SR')−SR" (asymmetric dithioacetals).
Cyclic acetals (8 C) Pages in category "Protecting groups" The following 19 pages are in this category, out of 19 total. This list may not reflect recent changes. ...
Different protecting groups on either the glycosyl donor or the glycosyl acceptor [4] [5] may affect the reactivity and yield of the glycosylation reaction. Typically, electron-withdrawing groups such as acetyl or benzoyl groups are found to decrease the reactivity of the donor/acceptor and are therefore termed "disarming" groups.
Benzylidene acetals are used as protecting groups in glycochemistry. [1] [2] These compounds can also be oxidized to carboxylic acids in order to open important biological molecules, such as glycosaminoglycans, to other routes of synthesis. [3] They arise from the reaction of a 1,2- or 1,3-diols with benzaldehyde. Other aromatic aldehydes are ...