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In mammals, four beta subunits have been described, called activin β A, activin β B, activin β C and activin β E. Activin β A and β B are identical to the two beta subunits of inhibin. A fifth subunit, activin β D, has been described in Xenopus laevis. Two activin β A subunits give rise to activin A, one β A, and one β B subunit gives ...
Inhibin, beta A, also known as INHBA, is a protein which in humans is encoded by the INHBA gene. [5] INHBA is a subunit of both activin and inhibin , two closely related glycoproteins with opposing biological effects.
3625 16324 Ensembl ENSG00000163083 ENSMUSG00000037035 UniProt P09529 Q04999 RefSeq (mRNA) NM_002193 NM_008381 RefSeq (protein) NP_002184 NP_032407 Location (UCSC) Chr 2: 120.35 – 120.35 Mb Chr 1: 119.34 – 119.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inhibin, beta B, also known as INHBB, is a protein which in humans is encoded by the INHBB gene. INHBB is a subunit of ...
Follistatin, also known as activin-bindings protein, is a protein that in humans is encoded by the FST gene. [ 5 ] [ 6 ] Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals.
There are three activins: Activin A, Activin B and Activin AB. Activins are involved in embryogenesis and osteogenesis. They also regulate many hormones including pituitary, gonadal and hypothalamic hormones as well as insulin. They are also nerve cell survival factors. The BMPs bind to the bone morphogenetic protein receptor type-2 (BMPR2).
Activin plays a significant role in reproduction. ACVR2 receptors are present in the testis during testicular development. [2] ACR2A and ACVR2B was found to be localized primarily in the gonocytes as well as in sertoli cells. [2] These cells are responsive to both autocrine and paracrine activin B signaling, which controls their proliferation. [2]
3623 16322 Ensembl ENSG00000123999 ENSMUSG00000032968 UniProt P05111 Q04997 RefSeq (mRNA) NM_002191 NM_010564 NM_001329843 RefSeq (protein) NP_002182 NP_001316772 NP_034694 Location (UCSC) Chr 2: 219.57 – 219.58 Mb Chr 1: 75.48 – 75.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inhibin, alpha, also known as INHA, is a protein which in humans is encoded by the INHA gene ...
16325 Ensembl ENSG00000175189 ENSMUSG00000025405 UniProt P55103 P55104 RefSeq (mRNA) NM_005538 NM_010565 RefSeq (protein) NP_005529 NP_034695 Location (UCSC) Chr 12: 57.43 – 57.45 Mb Chr 10: 127.19 – 127.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene. This gene encodes the beta C chain of inhibin, a ...