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direct stimulation of cannabinoid receptors in the digestive system. It has been hypothesized that certain people may be genetically pre-disposed to metabolize cannabinoids in an atypical manner, making them susceptible to CHS. [20] [21] Another cannabinoid called cannabigerol acts as an antagonist at cannabinoid and serotonin receptors ...
Cannabinoid-mediated inhibition of electric potentials results in a reduction in noradrenaline release from sympathetic nervous system nerves. Other studies have found similar effects in endocannabinoid regulation of intestinal motility, including the innervation of smooth muscles associated with the digestive, urinary, and reproductive systems ...
A dried cannabis flower. The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
Cannabis sativa from Vienna Dioscurides, 512 AD. A 2013 literature review by Gordon and colleagues concluded that inhaled cannabis is associated with lung disease, [3] although Tashkin's 2013 review has found "no clear link to chronic obstructive pulmonary disease". [83] Long-term effects of smoking cannabis include lung inflammation. [90]
Activation of cannabinoid receptors temporarily reduces the amount of conventional neurotransmitter released. This endocannabinoid-mediated system permits the postsynaptic cell to control its own incoming synaptic traffic. The ultimate effect on the endocannabinoid-releasing cell depends on the nature of the conventional transmitter being ...
“The cannabinoid system is widespread in the brain, so modulating cannabinoid function with products like THC could have a wide range of possible effects. We wanted to better understand which ...
THC, as well as the two major endogenous compounds identified so far that bind to the cannabinoid receptors —anandamide and 2-arachidonylglycerol (2-AG)— produce most of their effects by binding to both the CB 1 and CB 2 cannabinoid receptors. While the effects mediated by CB 1, mostly in the central nervous system, have been thoroughly ...
The process appears to set off a wound-healing reaction, and when people use cannabis, the cannabinoids bind to these receptors in the same way. [ 137 ] Previous studies have shown that CB1 receptors located on the nerve cells in the gut respond to cannabinoids by slowing gut motility , therefore reducing the painful muscle contractions ...